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The Pathogenesis of Bacterial Infections

The Pathogenesis Of Bacterial Infections


G. G. Jackson The pathogenesis of bacterial infection defines the dynamics at an interface of ecologic association of bacteria and host. First, it occurs at the portal of initial contact with a per missive target cell. The infected cell provides either a passive or a specific receptor for the bacterium or its products, to gether with ligands and an environment of helper and inhibiting factors. The result is bacterial replication to produce an im balance of a potentially commensal relation which, under other defined conditions, would be optimal for the survival of both the host and bacterial cells. Virulence and pathogenesis are both absolute and relative terms. They must be interpreted strictly according to the circumstances of site-specific inter actions of bacterial and host cells, membrane composition, structure, characteristics, and environmental substances. The bacteria themselves may have, acquire, or switch on or off under certain conditions, the products or properties that produce cellular damage that we recognize as virulence. Another result of bacterial infection may be to stimulate a normal host cell function to perform at a pathophysiologic level, causing illness that we recognize as virulence. A third marker of virulence may be the ability to invade a cell or tissue barrier and produce a pathologic effect at a site that is remote from the portal of commensal association or pathologic entry.



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    Conditions Guide
  • Format: Paperback
  • Sold by: --
  • Language: English
  • Publisher: Springer Verlag
  • ISBN-13: 9783642703539
  • ISBN: 3642703534
  • Publication Year: 2011
  • Edition: Reprint
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HPB condition ratings
  • New: Item is brand new, unused and unmarked, in flawless condition.
  • Fine/Like New (F): No defects, little usage. May show remainder marks. Older books may show minor flaws.
  • Very Good (VG): Shows some signs of wear and is no longer fresh. Attractive. Used textbooks do not come with supplemental materials.
  • Good (G): Average used book with all pages present. Possible loose bindings, highlighting, cocked spine or torn dust jackets. Used textbooks do not come with supplemental materials.
  • Fair (FR): Obviously well-worn, but no text pages missing. May be without endpapers or title page. Markings do not interfere with readability. Used textbooks do not come with supplemental materials.
  • Poor (P): All text is legible but may be soiled and have binding defects. Reading copies and binding copies fall into this category. Used textbooks do not come with supplemental materials.
Conditions Guide
HPB condition ratings
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Conditions Guide
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Conditions Guide
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